| Player | RBIs |
|---|---|
| Babe Ruth | 567 |
| Lou Gehrig | 541 |
| Hank Greenberg | 537 |
| Jimmie Foxx | 536 |
| Rogers Hornsby | 521 |
| Mike Schmidt | 484 |
| Frank Robinson | 477 |
| Stan Musial | 472 |
| Honus Wagner | 469 |
| Ted Williams | 465 |
| Willie Mays | 437 |
| Joe DiMaggio | 432 |
| Al Simmons | 425 |
| Mickey Mantle | 419 |
| Ty Cobb | 416 |
| Joe Jackson | 415 |
| Jackie Robinson | 406 |
| Nap Lajoie | 393 |
| Hank Aaron | 392 |
| Johnny Bench | 390 |
| Mickey Cochrane | 384 |
| Bill Dickey | 381 |
| Harry Heilmann | 374 |
| Ed Delahanty | 374 |
| Frank Thomas | 366 |
| Mel Ott | 354 |
| Willie McCovey | 349 |
| George Brett | 348 |
| Carl Yastrzemski | 342 |
| Duke Snider | 338 |