| Player | Strikeouts |
|---|---|
| Mike Schmidt | 599 |
| Jimmie Foxx | 585 |
| Mickey Mantle | 577 |
| Babe Ruth | 526 |
| Hank Greenberg | 504 |
| Frank Robinson | 472 |
| Lou Gehrig | 464 |
| Johnny Bench | 457 |
| Willie Mays | 439 |
| Duke Snider | 414 |
| Willie McCovey | 400 |
| Harmon Killebrew | 394 |
| Rickey Henderson | 393 |
| Reggie Jackson | 381 |
| Ernie Banks | 370 |
| Kirby Puckett | 366 |
| Rogers Hornsby | 362 |
| Al Simmons | 360 |
| Ted Williams | 348 |
| Harry Heilmann | 345 |
| Joe Morgan | 337 |
| Will Clark | 335 |
| Frank Thomas | 333 |
| Eddie Collins | 330 |
| Ryne Sandberg | 329 |
| Rod Carew | 326 |
| Carl Yastrzemski | 324 |
| Tony Gwynn | 320 |
| Mel Ott | 312 |
| Chipper Jones | 307 |