| Player | Runs Allowed |
|---|---|
| Dazzy Vance | 234 |
| John Smoltz | 247 |
| Gaylord Perry | 262 |
| Stan Coveleski | 271 |
| Spud Chandler | 321 |
| Johan Santana | 329 |
| Sid Fernandez | 336 |
| Whitey Ford | 343 |
| Jim Bunning | 350 |
| Dizzy Dean | 377 |
| Mickey Welch | 379 |
| Catfish Hunter | 382 |
| Don Drysdale | 388 |
| Dean Chance | 394 |
| Robin Roberts | 395 |
| Babe P. Ruth | 398 |
| Carl Hubbell | 402 |
| Pedro Martinez | 404 |
| Bob Lemon | 409 |
| Denny McLain | 415 |
| Randy Johnson | 416 |
| Lefty Grove | 436 |
| Kid Nichols | 436 |
| Don Sutton | 441 |
| Ed Walsh | 455 |
| Addie Joss | 460 |
| Bret Saberhagen | 504 |
| Mordecai Brown | 505 |
| Curt Schilling | 510 |
| Walter Johnson | 514 |