| Player | Saves |
|---|---|
| Mariano Rivera | 52 |
| Spud Chandler | 29 |
| Johan Santana | 28 |
| Bruce Sutter | 25 |
| Randy Johnson | 25 |
| Rollie Fingers | 24 |
| Hoyt Wilhelm | 16 |
| Dennis Eckersley | 16 |
| John Smoltz | 15 |
| Mordecai Brown | 13 |
| Rich Gossage | 11 |
| Walter Johnson | 11 |
| Lee Smith | 11 |
| Stan Coveleski | 10 |
| Roy Halladay | 10 |
| Warren Spahn | 9 |
| Cy Young | 9 |
| Dazzy Vance | 8 |
| Pedro Martinez | 7 |
| Lefty Grove | 6 |
| Sparky Lyle | 5 |
| Bob Lemon | 5 |
| Don Drysdale | 5 |
| Herb Score | 5 |
| Hal Newhouser | 4 |
| Dizzy Dean | 4 |
| Gaylord Perry | 4 |
| Vida Blue | 4 |
| Dan Quisenberry | 4 |
| Whitey Ford | 3 |