| Player | Strikeouts |
|---|---|
| Rube Waddell | 939 |
| Sandy Koufax | 870 |
| Nolan Ryan | 870 |
| Randy Johnson | 816 |
| Pedro Martinez | 756 |
| Walter Johnson | 693 |
| Tom Seaver | 683 |
| Bob Gibson | 679 |
| Curt Schilling | 656 |
| Ed Walsh | 643 |
| Christy Mathewson | 617 |
| Ed Plank | 582 |
| Steve Carlton | 566 |
| Chief Bender | 553 |
| Bert Blyleven | 529 |
| Pete Alexander | 513 |
| Johan Santana | 499 |
| Bob Feller | 494 |
| Mordecai Brown | 483 |
| Juan Marichal | 482 |
| Greg Maddux | 480 |
| Jack Chesbro | 477 |
| Cy Young | 470 |
| Don Sutton | 455 |
| Addie Joss | 451 |
| Vic Willis | 443 |
| Sid Fernandez | 414 |
| Bret Saberhagen | 410 |
| Lefty Grove | 409 |
| Dean Chance | 405 |