| Player | Season | RBIs |
|---|---|---|
| Hank Greenberg (STL) | 3 | 186 |
| Chuck Klein (ELP) | 3 | 165 |
| Willie Mays (SPB) | 3 | 163 |
| Lou Gehrig (VGA) | 3 | 161 |
| Babe Ruth (GRR) | 3 | 159 |
| Babe Ruth (GRR) | 4 | 159 |
| Mike Schmidt (VGA) | 3 | 157 |
| Lou Gehrig (VGA) | 4 | 152 |
| Rogers Hornsby (VGA) | 1 | 151 |
| Jimmie Foxx (OTT) | 1 | 141 |
| Jimmie Foxx (OTT) | 2 | 140 |
| Rogers Hornsby (ELP) | 3 | 139 |
| Frank Thomas (OTT) | 1 | 137 |
| Joe DiMaggio (OTT) | 3 | 136 |
| Ted Williams (PTL) | 3 | 136 |
| Jimmie Foxx (PTL) | 3 | 134 |
| Hank Greenberg (VGA) | 2 | 132 |
| Frank Thomas (VGA) | 4 | 132 |
| Willie McCovey (NOH) | 3 | 131 |
| Babe Ruth (STL) | 2 | 131 |
| Hank Aaron (GRR) | 1 | 130 |
| Stan Musial (GRR) | 4 | 128 |
| Mike Schmidt (VGA) | 4 | 128 |
| Frank Robinson (GRR) | 1 | 127 |
| Honus Wagner (NOH) | 3 | 127 |
| Frank Robinson (STL) | 2 | 126 |
| Carl Yastrzemski (PTL) | 1 | 125 |
| Ted Williams (NOH) | 2 | 124 |
| Mickey Mantle (STL) | 1 | 123 |
| Nap Lajoie (OTT) | 3 | 122 |