| Player | Season | Strikeouts |
|---|---|---|
| Mike Schmidt (VGA) | 4 | 178 |
| Mickey Mantle (STL) | 3 | 171 |
| Jim Rice (PTL) | 1 | 158 |
| Jimmie Foxx (OTT) | 2 | 154 |
| Reggie Jackson (PTL) | 1 | 153 |
| Mickey Mantle (STL) | 1 | 151 |
| Reggie Jackson (NOH) | 3 | 148 |
| Jimmie Foxx (PTL) | 3 | 147 |
| Mike Schmidt (PTL) | 2 | 145 |
| Duke Snider (GRR) | 4 | 143 |
| Jimmie Foxx (OTT) | 1 | 142 |
| Jimmie Foxx (PTL) | 4 | 142 |
| Babe Ruth (NOH) | 1 | 142 |
| Mike Schmidt (PTL) | 1 | 141 |
| Babe Ruth (GRR) | 3 | 137 |
| Eddie Mathews (SPB) | 1 | 135 |
| Willie McCovey (NOH) | 4 | 135 |
| Babe Ruth (STL) | 2 | 135 |
| Mike Schmidt (VGA) | 3 | 135 |
| Duke Snider (ELP) | 1 | 134 |
| Mickey Mantle (STL) | 4 | 132 |
| Willie McCovey (PTL) | 2 | 132 |
| Hank Greenberg (STL) | 3 | 131 |
| Frank Robinson (GRR) | 1 | 131 |
| Johnny Bench (GRR) | 4 | 127 |
| Lou Gehrig (SPB) | 2 | 127 |
| Hank Greenberg (VGA) | 1 | 127 |
| Frank Robinson (STL) | 3 | 127 |
| Willie McCovey (NOH) | 3 | 126 |
| Will Clark (SPB) | 3 | 125 |