| Player | Season | Innings Pitched |
|---|---|---|
| Hoss Radbourn (SPB) | 1 | 314.667 |
| Joe McGinnity (SPB) | 1 | 301.000 |
| John Ward (OTT) | 1 | 300.667 |
| Tim Keefe (VGA) | 1 | 288.333 |
| Joe McGinnity (ELP) | 3 | 276.800 |
| Walter Johnson (OTT) | 3 | 274.000 |
| Christy Mathewson (VGA) | 4 | 274.000 |
| Pete Alexander (SPB) | 4 | 271.800 |
| Ed Walsh (NOH) | 3 | 270.800 |
| Addie Joss (STL) | 3 | 266.200 |
| Walter Johnson (OTT) | 4 | 265.200 |
| Ed Walsh (NOH) | 4 | 265.100 |
| Mordecai Brown (NOH) | 3 | 265.000 |
| Cy Young (GRR) | 2 | 264.663 |
| Ed Plank (STL) | 1 | 264.000 |
| Christy Mathewson (PTL) | 1 | 262.000 |
| Addie Joss (SPB) | 2 | 260.333 |
| Chief Bender (PTL) | 4 | 259.000 |
| Rube Waddell (OTT) | 3 | 259.000 |
| Cy Young (OTT) | 1 | 259.000 |
| Addie Joss (OTT) | 1 | 258.667 |
| Pete Alexander (PTL) | 2 | 258.330 |
| Ed Plank (STL) | 4 | 257.900 |
| Pete Alexander (SPB) | 3 | 257.700 |
| Pete Alexander (OTT) | 1 | 257.333 |
| Juan Marichal (STL) | 4 | 256.700 |
| Babe P. Ruth (SPB) | 4 | 256.300 |
| Joe McGinnity (ELP) | 2 | 254.000 |
| Rube Waddell (SPB) | 2 | 253.997 |
| Christy Mathewson (VGA) | 3 | 253.000 |