| Player | Season | Runs Allowed |
|---|---|---|
| Don Sutton (NOH) | 2 | 84 |
| Chief Bender (SPB) | 2 | 89 |
| Addie Joss (SPB) | 2 | 92 |
| Sandy Koufax (STL) | 2 | 95 |
| Denny McLain (NOH) | 2 | 98 |
| Nolan Ryan (STL) | 2 | 99 |
| Spud Chandler (STL) | 3 | 101 |
| Carl Hubbell (VGA) | 2 | 101 |
| Dean Chance (SPB) | 2 | 103 |
| Bob Lemon (OTT) | 2 | 103 |
| Don Drysdale (STL) | 3 | 104 |
| Addie Joss (STL) | 4 | 106 |
| Randy Johnson (GRR) | 2 | 107 |
| Don Sutton (NOH) | 1 | 107 |
| Carl Mays (SPB) | 1 | 109 |
| Tom Seaver (GRR) | 2 | 110 |
| Carl Hubbell (STL) | 1 | 111 |
| Greg Maddux (VGA) | 1 | 111 |
| Mordecai Brown (NOH) | 2 | 113 |
| Sid Fernandez (STL) | 3 | 113 |
| Bob Gibson (GRR) | 4 | 113 |
| Walter Johnson (VGA) | 1 | 113 |
| Jim Palmer (ELP) | 2 | 113 |
| Don Sutton (NOH) | 3 | 113 |
| Pedro Martinez (VGA) | 3 | 114 |
| Ed Walsh (ELP) | 1 | 114 |
| Tom Glavine (PTL) | 2 | 115 |
| Christy Mathewson (NOH) | 2 | 116 |
| Jim Palmer (PTL) | 1 | 116 |
| Pedro Martinez (VGA) | 4 | 117 |