| Player | Season | Saves |
|---|---|---|
| Mariano Rivera (SPB) | 2 | 22 |
| Bruce Sutter (VGA) | 2 | 22 |
| Spud Chandler (STL) | 1 | 20 |
| Randy Johnson (NOH) | 3 | 18 |
| Johan Santana (OTT) | 1 | 18 |
| Mariano Rivera (VGA) | 1 | 14 |
| Mordecai Brown (NOH) | 1 | 12 |
| Mariano Rivera (SPB) | 3 | 11 |
| Rollie Fingers (VGA) | 3 | 10 |
| Walter Johnson (STL) | 2 | 10 |
| Hoyt Wilhelm (ELP) | 2 | 10 |
| Stan Coveleski (GRR) | 1 | 9 |
| Lee Smith (GRR) | 4 | 9 |
| Warren Spahn (PTL) | 1 | 9 |
| Roy Halladay (STL) | 4 | 8 |
| Cy Young (GRR) | 2 | 8 |
| Spud Chandler (STL) | 3 | 7 |
| Dennis Eckersley (PTL) | 3 | 7 |
| Randy Johnson (NOH) | 4 | 7 |
| Pedro Martinez (OTT) | 1 | 7 |
| Johan Santana (OTT) | 4 | 7 |
| John Smoltz (ELP) | 1 | 7 |
| Rollie Fingers (NOH) | 2 | 5 |
| Rollie Fingers (VGA) | 4 | 5 |
| Bob Lemon (OTT) | 2 | 5 |
| Mariano Rivera (SPB) | 4 | 5 |
| John Smoltz (PTL) | 2 | 5 |
| Vida Blue (SPB) | 1 | 4 |
| Dennis Eckersley (PTL) | 2 | 4 |
| Dennis Eckersley (PTL) | 4 | 4 |