| Player | Season | Strikeouts |
|---|---|---|
| Nolan Ryan (ELP) | 4 | 262 |
| Sandy Koufax (PTL) | 3 | 257 |
| Rube Waddell (OTT) | 3 | 246 |
| Randy Johnson (GRR) | 2 | 245 |
| Rube Waddell (STL) | 1 | 241 |
| Rube Waddell (OTT) | 4 | 241 |
| Pedro Martinez (VGA) | 4 | 234 |
| Randy Johnson (VGA) | 1 | 228 |
| Pedro Martinez (VGA) | 3 | 226 |
| Nolan Ryan (ELP) | 3 | 223 |
| Sandy Koufax (PTL) | 4 | 220 |
| Curt Schilling (OTT) | 3 | 217 |
| Rube Waddell (SPB) | 2 | 211 |
| Nolan Ryan (GRR) | 1 | 209 |
| Sandy Koufax (PTL) | 1 | 198 |
| Bob Gibson (GRR) | 3 | 196 |
| Sandy Koufax (STL) | 2 | 195 |
| Ed Walsh (NOH) | 3 | 192 |
| Tom Seaver (GRR) | 1 | 191 |
| Randy Johnson (NOH) | 3 | 189 |
| Roger Clemens (PTL) | 1 | 186 |
| Chief Bender (PTL) | 4 | 180 |
| Walter Johnson (STL) | 2 | 180 |
| Johan Santana (OTT) | 3 | 180 |
| Walter Johnson (OTT) | 4 | 178 |
| Nolan Ryan (STL) | 2 | 176 |
| Bob Gibson (GRR) | 1 | 175 |
| Chief Bender (PTL) | 3 | 174 |
| Steve Carlton (OTT) | 4 | 174 |
| Bert Blyleven (ELP) | 3 | 173 |